Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy

Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy

Blog Article

PURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy.MATERIALS AND METHODS:A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy.The median follow-up period was 34.5 months (range, 12 to 228 months).In this cohort, four types of urinary diversions were studied, including ilealneobladder jumpers (n = 24), ileocecalneobladder (n = 12), ileal conduit (n = 25), and cutaneous ureterostomy (n = 9).

Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated.The variables analyzed were age, a prior history of hypertension or diabetes mellitus, pre-operative renal function, type of urinary diversion, the postoperative occurrence of acute pyelonephritis, and the presence of chemotherapy.RESULTS: The mean eGFR was 74.6 (range, 15.2 to 155.

1) mL/min/1.73 m2 before surgery and 63.6 (range, 8.7 to 111.5) mL/min/1.

73 m2 at the last follow-up.The Positive Battery Terminal 10-year renal deterioration-free interval was 63.8%.Multivariate analysis showed that a postoperative episode of acute pyelonephritis [Odds Ratio (OR), 3.21; 95% Confidence Interval (CI), 1.

14 to 9.02; P =.03] and the presence of chemotherapy (OR, 3.27; 95% CI, 1.33 to 8.

01; P =.01) were significant adverse factors.CONCLUSION: Twenty-four (34.2%) patients demonstrated reduced renal function during the follow-up period.Postoperative episodes of acute pyelonephritis and the presence of chemotherapy were found to be significant adverse factors.